mif - An Overview
mif - An Overview
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MIF function and signaling. MIF fulfills its biological functions click here as a result of membrane receptors and via binding to intracellular molecules. MIF’s binding to membrane receptor CD74 recruits CD44 and results in activation of Src/MAPK signaling. MIF by way of CXCR2/four activates PI3K/Akt downstream signaling and induces cell migration. Sustained activation of ERK1/two phosphorylation is mediated by JUN activation domain binding protein-one (JAB1) and leads to cytoplasmic phospholipase A2 (cPLA2) action (blocked by glucocorticoids) and even more to arachidonate/prostaglandin generation. MIF creation might be stimulated via TLRs by e.g., LPS stimulation.
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The receptor that mediated MIF activity remained elusive till a research in 2003, which utilized a cDNA library and fluorescently conjugated MIF to monitor for a receptor and determined CD74 as being the MIF receptor. The authors described that MIF bound to the extracellular area of CD74, leading to extracellular signal-regulated kinase (ERK) pathway activation (twenty five).
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This review concentrates on the modern innovations that have considerably contributed to our latest understanding of the backlink between the signaling pathways activated upon binding of macrophage migration inhibitory component cytokine to its membrane receptor CD74 and wound healing in several system elements (determine one).
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